Publications

Bekturova, A., Makaros, Y., Ben-David, S., Koren, I. (2025) Global Profiling of N-terminal Cysteine-Dependent Degradation Mechanisms. bioRxiv https://doi.org/10.1101/2025.01.20.633921

Shimshon, A.*, Dahan, K.*, Israel-Gueta, M., Olmayev-Yaakobov, D., Timms, R.T., Bekturova, A., Makaros, Y., Elledge, S.J., Koren, I. (2024) Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability. JCB, Aug 5;223(8):e202311035. doi: 10.1083/jcb.202311035.  *Equally contributed

Chen, X.*, Raiff, A.*, Li, S., Guo, Q., Zhang, J., Timms, R.T., Yao, X., Elledge, S.J., Koren, I. #, Zhang, K.#, Xu, C.# (2024) Molecular insights into the CRL2FEM1B ubiquitin ligase complex assembly and recognition of Ψ/Pro/C-degron. Nat Commun, 15(1):3558. *Equally contributed;  #Co-Corresponding author. DOI: 10.1038/s41467-024-47890-5
 
Zhao, S.*, Olmayev-Yaakobov, D.*, Ru, W., Li, S., Chen, X., Zhang, J., Yao, X., Koren, I.#, Zhang, K.#, and Xu, C.# (2023). Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase. Proc Natl Acad Sci U S A 120, e2308870120.  #Co-Corresponding author. https://doi.org/10.1073/pnas.2308870120

Timms, R.T., Mena, E.L., Leng, Y., Li, M.Z., Tchasovnikarova, I.A., Koren, I., and Elledge, S.J. (2023). Defining E3 ligase–substrate relationships through multiplex CRISPR screening. Nat Cell Biol 25, 1535–1545.  https://doi.org/10.1038/s41556-023-01229-2

Makaros Y, Raiff A, Timms RT, Wagh AR, Bekturova A, Israel MG, Guez-Haddad J, Brodsky S, Opatowsky Y, Glickman MH, Elledge SJ, Koren I (2023) Ubiquitin-independent proteasomal degradation driven by C-degron pathways. Molecular Cell 83, 1921-1935. https://doi.org/10.1016/j.molcel.2023.04.023

Chen, X.*, Liao, S.*, Makaros, Y.*, Guo, Q., Zhu, Z., Krizelman, R., Dahan, K., Tu, X., Yao, X., Koren, I.#, Xu, C.# (2020) Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase. Nat. Chem. Biol.  *Equally contributed;  #Co-Corresponding author. https://doi.org/10.1038/s41589-020-00704-3

Timms, RT#,  Koren, I# (2020) Tying up loose ends: the N-degron and C-degron pathways of protein degradation. Biochem Soc Trans BST20191094. #Co-Correspondence author.  https://doi.org/10.1042/BST2019109

Timms, RT., Zhang, Z., Rhee DY., Harper JW., Koren, I.#, Elledge, SJ.# (2019) A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science, 365(6448).
#Co-Corresponding author.  https://doi.org/10.1126/science.aaw4912

Koren, I., Timms, RT., Kula, T., Xu, Q., Li, MZ., and Elledge, SJ. (2018). The Eukaryotic Proteome is Shaped by E3 Ubiquitin Ligases Targeting C-terminal Degrons. Cell 173, 1622-1635. https://doi.org/10.1016/j.cell.2018.04.028