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Publications

Makaros Y, Raiff A, Timms RT, Wagh AR, Bekturova A, Israel MG, Guez-Haddad J, Brodsky S, Opatowsky Y, Glickman MH, Elledge SJ, Koren I (2023) Ubiquitin-independent proteasomal degradation driven by C-degron pathways. Molecular Cell 83, 1921-1935

Chen, X.*, Liao, S.*, Makaros, Y.*, Guo, Q., Zhu, Z., Krizelman, R., Dahan, K., Tu, X., Yao, X., Koren, I.#, Xu, C.# (2020) Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase. Nat. Chem. Biol.  https://doi.org/10.1038/s41589-020-00704-3  *Equally contributed;  #Co-Corresponding author

Timms, RT*,  Koren, I* (2020) Tying up loose ends: the N-degron and C-degron pathways of protein degradation. Biochem Soc Trans BST20191094. *Co-Correspondence author

Timms, RT., Zhang, Z., Rhee DY., Harper JW., Koren, I.*, Elledge, SJ.* (2019) A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science, 365(6448).

*Co-Corresponding author

Koren, I., Timms, RT., Kula, T., Xu, Q., Li, MZ., and Elledge, SJ. (2018). The Eukaryotic Proteome is Shaped by E3 Ubiquitin Ligases Targeting C-terminal Degrons. Cell 173, 1622-1635.

Somekh, J., Peleg, M., Eran, A., Koren, I., Feiglin, A., Demishtein, A., Shiloh, R., Heiner, M., Kong, S.W., Elazar, Z., et al. (2016). A model-driven methodology for exploring complex disease comorbidities applied to autism spectrum disorder and inflammatory bowel disease. J Biomed Inform 63, 366-378

Elia, A.E., Boardman, A.P., Wang, D.C., Huttlin, E.L., Everley, R.A., Dephoure, N., Zhou, C., Koren, I., Gygi, S.P., and Elledge, S.J. (2015). Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response. Mol Cell 59, 867-881.

Koren, I., and Kimchi, A. (2012). Cell biology. Promoting tumorigenesis by suppressing autophagy. Science 338, 889-890.

Koren, I., Reem, E., and Kimchi, A. (2010). Autophagy gets a brake: DAP1, a novel mTOR substrate, is activated to suppress the autophagic process. Autophagy 6, 1179-1180

Koren, I., Reem, E., and Kimchi, A. (2010). DAP1, a novel substrate of mTOR, negatively regulates autophagy. Curr Biol 20, 1093-1098.

Zalckvar, E., Berissi, H., Mizrachy, L., Idelchuk, Y., Koren, I., Eisenstein, M., Sabanay, H., Pinkas-Kramarski, R., and Kimchi, A. (2009). DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep 10, 285-292.

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