top of page
protein degradation pathways


Publications
Bekturova, A., Makaros, Y., Ben-David, S., Koren, I. (2025) Global Profiling of N-terminal Cysteine-Dependent Degradation Mechanisms. bioRxiv https://doi.org/10.1101/2025.01.20.633921
Shimshon, A.*, Dahan, K.*, Israel-Gueta, M., Olmayev-Yaakobov, D., Timms, R.T., Bekturova, A., Makaros, Y., Elledge, S.J., Koren, I. (2024) Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability. JCB, Aug 5;223(8):e202311035. doi: 10.1083/jcb.202311035. *Equally contributed
Chen, X.*, Raiff, A.*, Li, S., Guo, Q., Zhang, J., Timms, R.T., Yao, X., Elledge, S.J., Koren, I. #, Zhang, K.#, Xu, C.# (2024) Molecular insights into the CRL2FEM1B ubiquitin ligase complex assembly and recognition of Ψ/Pro/C-degron. Nat Commun, 15(1):3558. *Equally contributed; #Co-Corresponding author. DOI: 10.1038/s41467-024-47890-5
Zhao, S.*, Olmayev-Yaakobov, D.*, Ru, W., Li, S., Chen, X., Zhang, J., Yao, X., Koren, I.#, Zhang, K.#, and Xu, C.# (2023). Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase. Proc Natl Acad Sci U S A 120, e2308870120. #Co-Corresponding author. https://doi.org/10.1073/pnas.2308870120
Timms, R.T., Mena, E.L., Leng, Y., Li, M.Z., Tchasovnikarova, I.A., Koren, I., and Elledge, S.J. (2023). Defining E3 ligase–substrate relationships through multiplex CRISPR screening. Nat Cell Biol 25, 1535–1545. https://doi.org/10.1038/s41556-023-01229-2
Makaros Y, Raiff A, Timms RT, Wagh AR, Bekturova A, Israel MG, Guez-Haddad J, Brodsky S, Opatowsky Y, Glickman MH, Elledge SJ, Koren I (2023) Ubiquitin-independent proteasomal degradation driven by C-degron pathways. Molecular Cell 83, 1921-1935. https://doi.org/10.1016/j.molcel.2023.04.023
Chen, X.*, Liao, S.*, Makaros, Y.*, Guo, Q., Zhu, Z., Krizelman, R., Dahan, K., Tu, X., Yao, X., Koren, I.#, Xu, C.# (2020) Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase. Nat. Chem. Biol. *Equally contributed; #Co-Corresponding author. https://doi.org/10.1038/s41589-020-00704-3
Timms, RT#, Koren, I# (2020) Tying up loose ends: the N-degron and C-degron pathways of protein degradation. Biochem Soc Trans BST20191094. #Co-Correspondence author. https://doi.org/10.1042/BST2019109
Timms, RT., Zhang, Z., Rhee DY., Harper JW., Koren, I.#, Elledge, SJ.# (2019) A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science, 365(6448).
#Co-Corresponding author. https://doi.org/10.1126/science.aaw4912
Koren, I., Timms, RT., Kula, T., Xu, Q., Li, MZ., and Elledge, SJ. (2018). The Eukaryotic Proteome is Shaped by E3 Ubiquitin Ligases Targeting C-terminal Degrons. Cell 173, 1622-1635. https://doi.org/10.1016/j.cell.2018.04.028
bottom of page